Nisha Parikh, MD

Assoc. Professor Clinical
+1 415 514-0992

Clinical Interests: Dr. Parikh is a noninvasive cardiologist. Her interests are in primary and secondary cardiovascular disease prevention and women's cardiovascular diseases across the lifespan; including cardiovascular disease in pregnancy and the post-partum period.

Research Interests: Dr. Parikh is a trained cardiovascular epidemiologist and population scientist. She demonstrated in the Multi-Ethnic Study of Atherosclerosis that the hemodynamic changes of pregnancy may not revert back to normal, may be cumulative across successive pregnancies, and can lead to left ventricular remodeling on cardiac MRI in mid-life. Along with a research team at the Framingham Heart Study, she developed a risk score for incident hypertension and this work was cited in the recent version of the US hypertension guidelines. She has added to the scientific knowledge base demonstrating which specific reproductive factors are predictors of cardiovascular disease using data from the NIH sponsored Women's Health Initiative Study and has leveraged data from the Swedish Population Registers. Her work has been supported by grants from the American Heart Association, the NIH/National Heart Lung and Blood Institute and the UCSF Preterm Birth Initiative.

Other interests: Dr. Parikh has been an active volunteer for the American Heart Association (AHA) for over twelve years serving on many committees including Early Career, Leadership and others.

Publications: 

Cardiovascular events more than 6 months after pregnancy in patients with congenital heart disease.

Open heart

Schultz H, Sobhani NC, Blissett S, Yogeswaran V, Hong J, Harris IS, Parikh N, Gonzalez J, Agarwal A

Adverse pregnancy outcomes and risk of type 2 diabetes in postmenopausal women.

American journal of obstetrics and gynecology

Zhu K, Wactawski-Wende J, Mendola P, Parikh NI, Lamonte MJ, Barnabei VM, Hageman Blair R, Manson JE, Liu S, Wang M, Wild RA, Shadyab AH, Van Horn L, Leblanc ES, Sinkey R, Schnatz PF, Saquib N, Mu L

The effect of postpartum lifestyle interventions on blood pressure: a systematic literature review.

Journal of hypertension

Murray Horwitz ME, Tabani A, Brédy GS, Flynn DB, Edwards CV, Curran NJ, Parikh NI

Heart Disease and Stroke Statistics-2023 Update: A Report From the American Heart Association.

Circulation

Tsao CW, Aday AW, Almarzooq ZI, Anderson CAM, Arora P, Avery CL, Baker-Smith CM, Beaton AZ, Boehme AK, Buxton AE, Commodore-Mensah Y, Elkind MSV, Evenson KR, Eze-Nliam C, Fugar S, Generoso G, Heard DG, Hiremath S, Ho JE, Kalani R, Kazi DS, Ko D, Levine DA, Liu J, Ma J, Magnani JW, Michos ED, Mussolino ME, Navaneethan SD, Parikh NI, Poudel R, Rezk-Hanna M, Roth GA, Shah NS, St-Onge MP, Thacker EL, Virani SS, Voeks JH, Wang NY, Wong ND, Wong SS, Yaffe K, Martin SS, American Heart Association Council on Epidemiology and Prevention Statistics Committee and Stroke St

Association of Right Ventricular Dilation on Echocardiogram with In-Hospital Mortality Among Patients Hospitalized with COVID-19 Compared with Bacterial Pneumonia.

Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography

Sun K, Cedarbaum E, Hill C, Win S, Parikh NI, Hsue PY, Durstenfeld MS

Hospitalized Patients With COVID-19 Have Higher Plasma Aldosterone-Renin Ratio and Lower ACE Activity Than Controls.

Journal of the Endocrine Society

Parikh NI, Arowolo F, Durstenfeld MS, Nah G, Njoroge J, Vittinghoff E, Long CS, Ganz P, Pearce D, Hsue P, Wu AHS, Hajizadeh N, Liu KD, Lynch KL

Clinical Correlates and Outcomes of Methamphetamine-Associated Cardiovascular Diseases in Hospitalized Patients in California.

Journal of the American Heart Association

Curran L, Nah G, Marcus GM, Tseng Z, Crawford MH, Parikh NI

Association of infertility with atherosclerotic cardiovascular disease among postmenopausal participants in the Women's Health Initiative.

Fertility and sterility

Murugappan G, Leonard SA, Farland LV, Lau ES, Shadyab AH, Wild RA, Schnatz P, Carmichael SL, Stefanick ML, Parikh NI

Perinatal outcomes and 2017 ACC/AHA blood pressure categories.

Pregnancy hypertension

Tesfalul MA, Sperling JD, Blat C, Parikh NI, Gonzalez-Velez JM, Zlatnik MG, Norton ME

Adverse Pregnancy Outcomes and Incident Heart Failure in the Women's Health Initiative.

JAMA network open

Hansen AL, Søndergaard MM, Hlatky MA, Vittinghof E, Nah G, Stefanick ML, Manson JE, Farland LV, Wells GL, Mongraw-Chaffin M, Gunderson EP, Van Horn L, Wild RA, Liu B, Shadyab AH, Allison MA, Liu S, Eaton CB, Honigberg MC, Parikh NI

Predicting incident heart failure in women with machine learning: The Women's Health Initiative Cohort.

The Canadian journal of cardiology

Tison GH, Avram R, Nah G, Klein L, Howard BV, Allison MA, Casanova R, Blair RH, Breathett K, Foraker RE, Olgin JE, Parikh NI

Association of Adverse Pregnancy Outcomes With Risk of Atherosclerotic Cardiovascular Disease in Postmenopausal Women.

JAMA cardiology

Søndergaard MM, Hlatky MA, Stefanick ML, Vittinghoff E, Nah G, Allison M, Gemmill A, Van Horn L, Park K, Salmoirago-Blotcher E, Sattari M, Sealy-Jefferson S, Shadyab AH, Valdiviezo C, Manson JE, Parikh NI

Antimüllerian hormone and F2-isoprostanes in the Coronary Artery Risk Development in Young Adults (CARDIA) Study.

Fertility and sterility

Kim C, Slaughter JC, Terry JG, Jacobs DR, Parikh N, Appiah D, Leader B, Moravek MB, Wellons MF

Placental Abruption as a Risk Factor for Heart Failure.

The American journal of cardiology

DesJardin JT, Healy MJ, Nah G, Vittinghoff E, Agarwal A, Marcus GM, Velez JMG, Tseng ZH, Parikh NI

Maternal cardiovascular disease risk factors as predictors of preterm birth in California: a case-control study.

BMJ open

Rohlfing AB, Nah G, Ryckman KK, Snyder BD, Kasarek D, Paynter RA, Feuer SK, Jelliffe-Pawlowski L, Parikh NI

Cardiovascular Disease-Related Pregnancy Complications Are Associated with Increased Maternal Levels and Trajectories of Cardiovascular Disease Biomarkers During and After Pregnancy.

Journal of women's health (2002)

Parikh NI, Laria B, Nah G, Singhal M, Vittinghoff E, Vieten C, Stotland N, Coleman-Phox K, Adler N, Albert MA, Epel E

Associations between unstable housing, obstetric outcomes, and perinatal health care utilization.

American journal of obstetrics & gynecology MFM

Pantell MS, Baer RJ, Torres JM, Felder JN, Gomez AM, Chambers BD, Dunn J, Parikh NI, Pacheco-Werner T, Rogers EE, Feuer SK, Ryckman KK, Novak NL, Tabb KM, Fuchs J, Rand L, Jelliffe-Pawlowski LL

Impact of autoimmune rheumatic diseases on birth outcomes: a population-based study.

RMD open

Strouse J, Donovan BM, Fatima M, Fernandez-Ruiz R, Baer RJ, Nidey N, Forbess C, Bandoli G, Paynter R, Parikh N, Jeliffe-Pawlowski L, Ryckman KK, Singh N

Relation of Pregnancy Loss to Risk of Cardiovascular Disease in Parous Postmenopausal Women (From the Women's Health Initiative).

The American journal of cardiology

Hall PS, Nah G, Vittinghoff E, Parker DR, Manson JE, Howard BV, Sarto GE, Gass ML, Sealy-Jefferson SM, Salmoirago-Blotcher E, Stefanick ML, Shadyab AH, Van Horn LV, Park K, Parikh NI

Does Calculated Prognostic Estimation Lead to Different Outcomes Compared With Experience-Based Prognostication in the ICU? A Systematic Review.

Critical care explorations

Basile M, Press A, Adia AC, Wang JJ, Herman SW, Lester J, Parikh N, Hajizadeh N

Contraceptive Choices in the Immediate Postpartum Period in Women With Cardiac Disease.

The American journal of cardiology

Sobhani NC, Schultz H, Kheiwa A, Killion M, Parikh NI, Harris IS, Gonzalez JM, Agarwal A

Women's Reproductive History and Pre-Clinical Peripheral Arterial Disease in Late Life: The San Diego Population Study.

Journal of women's health (2002)

Cortés YI, Parikh N, Allison MA, Criqui MH, Suder N, Barinas-Mitchell E, Wassel CL

Effects of reproductive period duration and number of pregnancies on midlife ECG indices: a secondary analysis from the Women's Health Initiative Clinical Trial.

BMJ open

Parikh NI, Kapphahn K, Hedlin H, Olgin JE, Allison MA, Magnani JW, Ryckman KR, Waring ME, Perez MV, Howard BV

Association of Left Atrial Function Index with Atrial Fibrillation and Cardiovascular Disease: The Framingham Offspring Study.

Journal of the American Heart Association

Sardana M, Lessard D, Tsao CW, Parikh NI, Barton BA, Nah G, Thomas RC, Cheng S, Schiller NB, Aragam JR, Mitchell GF, Vaze A, Benjamin EJ, Vasan RS, McManus DD

Reply: Hormone Status Correlates With Incidence of Heart Failure.

Journal of the American College of Cardiology

Parikh NI, Hall PS

Clinical and Echocardiographic Correlates of Left Atrial Function Index: The Framingham Offspring Study.

Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography

Sardana M, Nah G, Tsao CW, Ogunsua AA, Vittinghoff E, Thomas RC, Cheng S, Vaze A, Aragam JR, Mitchell GF, Benjamin EJ, Vasan RS, Aurigemma GP, Schiller NB, McManus DD, Parikh NI

High Prevalence and Clinical/Sociodemographic Correlates of Miscarriages Among Flight Attendants.

The American journal of medicine

Heidecker B, Spencer RM, Hayes V, Hall S, Parikh N, Stock EO, Redberg R

Reproductive Factors and Incidence of Heart Failure Hospitalization in the Women's Health Initiative.

Journal of the American College of Cardiology

Hall PS, Nah G, Howard BV, Lewis CE, Allison MA, Sarto GE, Waring ME, Jacobson LT, Manson JE, Klein L, Parikh NI

Association of Pregnancy Complications and Characteristics With Future Risk of Elevated Blood Pressure: The Västerbotten Intervention Program.

Hypertension (Dallas, Tex. : 1979)

Parikh NI, Norberg M, Ingelsson E, Cnattingius S, Vasan RS, Domellöf M, Jansson JH, Edstedt Bonamy AK

Reproductive history and risk of type 2 diabetes mellitus in postmenopausal women: findings from the Women's Health Initiative.

Menopause (New York, N.Y.)

LeBlanc ES, Kapphahn K, Hedlin H, Desai M, Parikh NI, Liu S, Parker DR, Anderson M, Aroda V, Sullivan S, Woods NF, Waring ME, Lewis CE, Stefanick M

Association of Left Atrial Function Index With Late Atrial Fibrillation Recurrence after Catheter Ablation.

Journal of cardiovascular electrophysiology

Sardana M, Ogunsua AA, Spring M, Shaikh A, Asamoah O, Stokken G, Browning C, Ennis C, Donahue JK, Rosenthal LS, Floyd KC, Aurigemma GP, Parikh NI, McManus DD

Parity, coronary heart disease and mortality in the old order Amish.

Atherosclerosis

Elajami TK, Giuseffi J, Avila MD, Hovnanians N, Mukamal KJ, Parikh N, Welty FK

Reproductive Risk Factors and Coronary Heart Disease in the Women's Health Initiative Observational Study.

Circulation

Parikh NI, Jeppson RP, Berger JS, Eaton CB, Kroenke CH, LeBlanc ES, Lewis CE, Loucks EB, Parker DR, Rillamas-Sun E, Ryckman KK, Waring ME, Schenken RS, Johnson KC, Edstedt-Bonamy AK, Allison MA, Howard BV

Racial and ethnic differences in atrial fibrillation risk factors and predictors in women: Findings from the Women's Health Initiative.

American heart journal

Rodriguez F, Stefanick ML, Greenland P, Soliman EZ, Manson JE, Parikh N, Martin LW, Larson JC, Hlatky M, Nassir R, Cené CW, Rodriguez BL, Albert C, Perez MV

HIV and coronary artery calcium score: comparison of the Hawaii Aging with HIV Cardiovascular Study and Multi-Ethnic Study of Atherosclerosis (MESA) cohorts.

HIV clinical trials

Chow D, Young R, Valcour N, Kronmal RA, Lum CJ, Parikh NI, Tracy RP, Budoff M, Shikuma CM

Association between number of live births and markers of subclinical atherosclerosis: The Dallas Heart Study.

European journal of preventive cardiology

Sanghavi M, Kulinski J, Ayers CR, Nelson D, Stewart R, Parikh N, de Lemos JA, Khera A

Assessment of Obesity and Cardiovascular Risk in South Asians

Current Cardiovascular Risk Reports

Parikh NI, Aurora MS, Dash R, Shin JJ, Palaniappan L

Characterization of lipid composition and high-density lipoprotein function in HIV-infected individuals on stable antiretroviral regimens.

AIDS research and human retroviruses

Munger AM, Chow DC, Playford MP, Parikh NI, Gangcuangco LM, Nakamoto BK, Kallianpur KJ, Ndhlovu LC, Shikuma CM, Mehta NN

Lipoprotein concentration, particle number, size and cholesterol efflux capacity are associated with mitochondrial oxidative stress and function in an HIV positive cohort.

Atherosclerosis

Parikh NI, Gerschenson M, Bennett K, Gangcuangco LM, Lopez MS, Mehta NN, Playford MP, Nakamoto BK, Seto TB, Chow DC, Shikuma CM

Risk of cardiovascular disease among postmenopausal women with prior pregnancy loss: the women's health initiative.

Annals of family medicine

Parker DR, Lu B, Sands-Lincoln M, Kroenke CH, Lee CC, O'Sullivan M, Park HL, Parikh N, Schenken RS, Eaton CB

Ethnic differences in the relationship between birth weight and type 2 diabetes mellitus in postmenopausal women.

Diabetes & metabolism

Ryckman KK, Rillamas-Sun E, Spracklen CN, Wallace RB, Garcia L, Tylavsky FA, Howard BV, Liu S, Song Y, LeBlanc ES, White MV, Parikh NI, Robinson JG

Monocytes expand with immune dysregulation and is associated with insulin resistance in older individuals with chronic HIV.

PloS one

Shikuma CM, Chow DC, Gangcuangco LM, Zhang G, Keating SM, Norris PJ, Seto TB, Parikh N, Kallianpur KJ, Nakamoto BK, Nagamine LS, Ndhlovu LC, Barbour JD

Reduced CD14 expression on classical monocytes and vascular endothelial adhesion markers independently associate with carotid artery intima media thickness in chronically HIV-1 infected adults on virologically suppressive anti-retroviral therapy.

Atherosclerosis

Barbour JD, Jalbert EC, Chow DC, Gangcuangco LM, Norris PJ, Keating SM, Heitman J, Nagamine L, Seto T, Ndhlovu LC, Nakamoto BK, Hodis HN, Parikh NI, Shikuma CM

Feasibility and potential role of ferumoxytol-enhanced neuroimaging in HIV-associated neurocognitive disorder.

Journal of neurovirology

Nakamoto BK, Shikuma CM, Ogata-Arakaki D, Umaki T, Neuwelt EA, Shiramizu BT, Chow DC, Parikh NI, Kallianpur KJ, Hamilton BE

The jugular venous pressure revisited.

Cleveland Clinic journal of medicine

Chua Chiaco JM, Parikh NI, Fergusson DJ

IL-1? enriched monocytes mount massive IL-6 responses to common inflammatory triggers among chronically HIV-1 infected adults on stable anti-retroviral therapy at risk for cardiovascular disease.

PloS one

Jalbert E, Crawford TQ, D'Antoni ML, Keating SM, Norris PJ, Nakamoto BK, Seto T, Parikh NI, Shikuma CM, Ndhlovu LC, Barbour JD

Plasma monocyte chemoattractant protein-1 and tumor necrosis factor-a levels predict the presence of coronary artery calcium in HIV-infected individuals independent of traditional cardiovascular risk factors.

AIDS research and human retroviruses

Shikuma CM, Barbour JD, Ndhlovu LC, Keating SM, Norris PJ, Budoff M, Parikh N, Seto T, Gangcuangco LM, Ogata-Arakaki D, Chow D

Rates of autonomic dysfunction in HIV patients receiving antiretroviral therapy.

Journal of neurovirology

Chow D, Nakamoto B, So E, Parikh N, Souza S, Kallianpur K, Shikuma C

Albuminuria as a marker of cardiovascular risk in HIV-infected individuals receiving stable antiretroviral therapy.

Hawai'i journal of medicine & public health : a journal of Asia Pacific Medicine & Public Health

Tongma C, Shikuma CM, Nakamoto BK, Kallianpur KJ, Umaki TM, Barbour JD, Ndhlovu L, Parikh NI, Chow DC

Methamphetamine-associated cardiomyopathy.

Clinical cardiology

Won S, Hong RA, Shohet RV, Seto TB, Parikh NI

Pregnancy Complications and the Risk of Metabolic Syndrome for the Offspring.

Current Cardiovascular Risk Reports

Ryckman KK, Borowski KS, Parikh NI, Saftlas AF

Current Cardiovascular Risk Reports. Eds. Robinson JF and Levy D

Predicting Women’s Future Cardiovascular Health from Pregnancy Complications.

Edstedt-Bonamy A-K, Parikh NI

The effects of extended release niacin on lipoprotein sub-particle concentrations in HIV-infected patients.

Hawai'i journal of medicine & public health : a journal of Asia Pacific Medicine & Public Health

Lin C, Grandinetti A, Shikuma C, Souza S, Parikh N, Nakamoto B, Kallianpur KJ, Chow D

Replication of genetic loci for ages at menarche and menopause in the multi-ethnic Population Architecture using Genomics and Epidemiology (PAGE) study.

Human reproduction (Oxford, England)

Carty CL, Spencer KL, Setiawan VW, Fernandez-Rhodes L, Malinowski J, Buyske S, Young A, Jorgensen NW, Cheng I, Carlson CS, Brown-Gentry K, Goodloe R, Park A, Parikh NI, Henderson B, Le Marchand L, Wactawski-Wende J, Fornage M, Matise TC, Hindorff LA, Arnold AM, Haiman CA, Franceschini N, Peters U, Crawford DC

Effects of antiretroviral therapy on autonomic function in early HIV infection: a preliminary report.

International journal of medical sciences

Chow D, Kocher M, Shikuma C, Parikh N, Grandinetti A, Nakamoto B, Seto T, Low P

Role of the veterans aging cohort study index in assessing total atherosclerotic burden.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

Chow D, Thomas BS, Liang CY, Souza SC, Nakamoto BK, Parikh NI, Shikuma C

Association of number of live births with left ventricular structure and function. The Multi-Ethnic Study of Atherosclerosis (MESA).

American heart journal

Parikh NI, Lloyd-Jones DM, Ning H, Ouyang P, Polak JF, Lima JA, Bluemke D, Mittleman MA

Subfertility and risk of later life maternal cardiovascular disease.

Human reproduction (Oxford, England)

Parikh NI, Cnattingius S, Mittleman MA, Ludvigsson JF, Ingelsson E

Sex differences in the risk of cardiovascular disease.

BMJ (Clinical research ed.)

Parikh NI

Parity and risk of later-life maternal cardiovascular disease.

American heart journal

Parikh NI, Cnattingius S, Dickman PW, Mittleman MA, Ludvigsson JF, Ingelsson E

Breastfeeding in infancy and adult cardiovascular disease risk factors.

The American journal of medicine

Parikh NI, Hwang SJ, Ingelsson E, Benjamin EJ, Fox CS, Vasan RS, Murabito JM

Visceral and subcutaneous adiposity and brachial artery vasodilator function.

Obesity (Silver Spring, Md.)

Parikh NI, Keyes MJ, Larson MG, Pou KM, Hamburg NM, Vita JA, O'Donnell CJ, Vasan RS, Mitchell GF, Hoffmann U, Fox CS, Benjamin EJ

Long-term trends in myocardial infarction incidence and case fatality in the National Heart, Lung, and Blood Institute's Framingham Heart study.

Circulation

Parikh NI, Gona P, Larson MG, Fox CS, Benjamin EJ, Murabito JM, O'Donnell CJ, Vasan RS, Levy D

Long-term trends in the incidence of heart failure after myocardial infarction.

Circulation

Velagaleti RS, Pencina MJ, Murabito JM, Wang TJ, Parikh NI, D'Agostino RB, Levy D, Kannel WB, Vasan RS

Clinical correlates and heritability of cystatin C (from the Framingham Offspring Study).

The American journal of cardiology

Parikh NI, Hwang SJ, Yang Q, Larson MG, Guo CY, Robins SJ, Sutherland P, Benjamin EJ, Levy D, Fox CS

Indexes of kidney function and coronary artery and abdominal aortic calcium (from the Framingham Offspring Study).

The American journal of cardiology

Parikh NI, Hwang SJ, Larson MG, Hoffmann U, Levy D, Meigs JB, O'Donnell CJ, Fox CS

Chronic kidney disease as a predictor of cardiovascular disease (from the Framingham Heart Study).

The American journal of cardiology

Parikh NI, Hwang SJ, Larson MG, Levy D, Fox CS

Overweight, obesity, and the development of stage 3 CKD: the Framingham Heart Study.

American journal of kidney diseases : the official journal of the National Kidney Foundation

Foster MC, Hwang SJ, Larson MG, Lichtman JH, Parikh NI, Vasan RS, Levy D, Fox CS

A risk score for predicting near-term incidence of hypertension: the Framingham Heart Study.

Annals of internal medicine

Parikh NI, Pencina MJ, Wang TJ, Benjamin EJ, Lanier KJ, Levy D, D'Agostino RB, Kannel WB, Vasan RS

Assessing the clinical utility of biomarkers in medicine.

Biomarkers in medicine

Parikh NI, Vasan RS

Plasma renin and risk of cardiovascular disease and mortality: the Framingham Heart Study.

European heart journal

Parikh NI, Gona P, Larson MG, Wang TJ, Newton-Cheh C, Levy D, Benjamin EJ, Kannel WB, Vasan RS

Parental occurrence of premature cardiovascular disease predicts increased coronary artery and abdominal aortic calcification in the Framingham Offspring and Third Generation cohorts.

Circulation

Parikh NI, Hwang SJ, Larson MG, Cupples LA, Fox CS, Manders ES, Murabito JM, Massaro JM, Hoffmann U, O'Donnell CJ

Cross-classification of microalbuminuria and reduced glomerular filtration rate: associations between cardiovascular disease risk factors and clinical outcomes.

Archives of internal medicine

Foster MC, Hwang SJ, Larson MG, Parikh NI, Meigs JB, Vasan RS, Wang TJ, Levy D, Fox CS

Increasing trends in incidence of overweight and obesity over 5 decades.

The American journal of medicine

Parikh NI, Pencina MJ, Wang TJ, Lanier KJ, Fox CS, D'Agostino RB, Vasan RS

Cardiovascular disease risk factors in chronic kidney disease: overall burden and rates of treatment and control.

Archives of internal medicine

Parikh NI, Hwang SJ, Larson MG, Meigs JB, Levy D, Fox CS

Images in cardiovascular medicine. Primary lymphoma of the heart.

Circulation

Kuvin J, Parikh N, Salomon R, Tischler A, Daoust P, Arshanskiy Y, Coyner K, Carpino P, Pandian NG, Kimmelstiel C, Foote C, Erban J, Rastegar H