Ethan Weiss, MD

Assoc Prof In Res
[email protected]

CLINICAL INTERESTS: Dr. Ethan Weiss is a cardiologist specializing in general cardiology. His special interests include preventive cardiology, genetics of coronary disease, risk assessment, and heart disease in the young.

RESEARCH INTERESTS: In his research, Dr. Weiss uses genetic models to better understand the mechanism of metabolic disorders such as obesity, fatty liver disease, and diabetes. He also studies the blood clotting system and has interest in identifying novel ways to safely block clots associated with diseases such as heart attack and stroke without causing an increase in bleeding.

Publications: 

An evolutionary trade-off between host immunity and metabolism drives fatty liver in male mice.

Science (New York, N.Y.)

Nikkanen J, Leong YA, Krause WC, Dermadi D, Maschek JA, Van Ry T, Cox JE, Weiss EJ, Gokcumen O, Chawla A, Ingraham HA

Three-dimensional optical body shape and features improve prediction of metabolic disease risk in a diverse sample of adults.

Obesity (Silver Spring, Md.)

Bennett JP, Liu YE, Quon BK, Kelly NN, Leong LT, Wong MC, Kennedy SF, Chow DC, Garber AK, Weiss EJ, Heymsfield SB, Shepherd JA

Assessment of clinical measures of total and regional body composition from a commercial 3-dimensional optical body scanner.

Clinical nutrition (Edinburgh, Scotland)

Bennett JP, Liu YE, Quon BK, Kelly NN, Wong MC, Kennedy SF, Chow DC, Garber AK, Weiss EJ, Heymsfield SB, Shepherd JA

Keyto App and Device versus WW App on Weight Loss and Metabolic Risk in Adults with Overweight or Obesity: A Randomized Trial.

Obesity (Silver Spring, Md.)

Falkenhain K, Locke SR, Lowe DA, Reitsma NJ, Lee T, Singer J, Weiss EJ, Little JP

A Mediterranean-Based Ketogenic Diet Application Compared to a Calorie-Restricted Low-Fat Diet Application on Cardiometabolic Risk in Adults With Overweight or Obesity.

Current Developments in Nutrition

Kaja Falkenhain, Sean Locke, Dylan Lowe, Nicholas Reitsma, Ethan Weiss, Jonathan Little

Caution Against Overinterpreting Time-Restricted Eating Results-Reply.

JAMA internal medicine

Weiss EJ, Lowe DA, Vittinghoff E

4ß-hydroxycholesterol is a pro-lipogenic factor that promotes SREBP1c expression and activity through Liver X-receptor.

Journal of lipid research

Moldavski O, Zushin PH, Berdan CA, Van Eijkeren RJ, Jiang X, Qian M, Ory DS, Covey DF, Nomura DK, Stahl A, Weiss EJ, Zoncu R

Effects of Time-Restricted Eating on Weight Loss and Other Metabolic Parameters in Women and Men With Overweight and Obesity: The TREAT Randomized Clinical Trial.

JAMA internal medicine

Lowe DA, Wu N, Rohdin-Bibby L, Moore AH, Kelly N, Liu YE, Philip E, Vittinghoff E, Heymsfield SB, Olgin JE, Shepherd JA, Weiss EJ

Comparing the Keyto App and Device with Weight Watchers' WW App for Weight Loss: Protocol for a Randomized Trial.

JMIR research protocols

Locke SR, Falkenhain K, Lowe DA, Lee T, Singer J, Weiss EJ, Little JP

Diet Quality and Visceral Adiposity among a Multiethnic Population of Young, Middle, and Older Aged Adults.

Current Developments in Nutrition

Panizza CE, Wong MC, Kelly N, Liu YE, Shvetsov YB, Lowe DA, Weiss EJ, Heymsfield SB, Kennedy S, Boushey CJ, Maskarinec G, Shepherd JA

MON-LB107 Treat: A Randomized Controlled Trial Examining the Effects of Time Restricted Eating on Weight Loss and Metabolic Markers.

Journal of the Endocrine Society

Dylan A Lowe, Ethan James Weiss, Jeffrey E Olgin, Eric Vittinghoff, John A Shepherd, Steven B Heymsfield, Linnea Rohdin-Bibby, Nisa Kelly, Nancy Wu

Billy Idol.

Perspectives in biology and medicine

Weiss EJ

Adipocyte JAK2 mediates spontaneous metabolic liver disease and hepatocellular carcinoma.

JCI insight

Corbit KC, Wilson CG, Lowe D, Tran JL, Vera NB, Clasquin M, Mattis AN, Weiss EJ

Adipocyte JAK2 Regulates Hepatic Insulin Sensitivity Independently of Body Composition, Liver Lipid Content, and Hepatic Insulin Signaling.

Diabetes

Corbit KC, Camporez JPG, Edmunds LR, Tran JL, Vera NB, Erion DM, Deo RC, Perry RJ, Shulman GI, Jurczak MJ, Weiss EJ

Adipocyte JAK2 mediates growth hormone-induced hepatic insulin resistance.

JCI insight

Corbit KC, Camporez JPG, Tran JL, Wilson CG, Lowe DA, Nordstrom SM, Ganeshan K, Perry RJ, Shulman GI, Jurczak MJ, Weiss EJ

Hepatocyte-Specific Disruption of CD36 Attenuates Fatty Liver and Improves Insulin Sensitivity in HFD-Fed Mice.

Endocrinology

Wilson CG, Tran JL, Erion DM, Vera NB, Febbraio M, Weiss EJ

Disruption of JAK2 in adipocytes impairs lipolysis and improves fatty liver in mice with elevated GH.

Molecular endocrinology (Baltimore, Md.)

Nordstrom SM, Tran JL, Sos BC, Wagner KU, Weiss EJ

HIV infection is associated with decreased thrombin generation.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

Hsue PY, Scherzer R, Grunfeld C, Nordstrom SM, Schnell A, Kohl LP, Nitta E, Martin JN, Deeks SG, Weiss EJ

Abrogation of growth hormone secretion rescues fatty liver in mice with hepatocyte-specific deletion of JAK2.

The Journal of clinical investigation

Sos BC, Harris C, Nordstrom SM, Tran JL, Balázs M, Caplazi P, Febbraio M, Applegate MA, Wagner KU, Weiss EJ

Genetic regulation of platelet receptor expression and function: application in clinical practice and drug development.

Arteriosclerosis, thrombosis, and vascular biology

Williams MS, Weiss EJ, Sabatine MS, Simon DI, Bahou WF, Becker LC, Parise LV, Dauerman HL, French PA, Smyth SS, Becker RC

Increased thrombosis susceptibility and altered fibrin formation in STAT5-deficient mice.

Blood

Nordstrom SM, Holliday BA, Sos BC, Smyth JW, Levy RE, Dukes JW, Lord ST, Weiss EJ

A Novel Tissue Factor Resistance Locus on Mouse Chromosome 11 Confers Protection from Thrombosis through Reduced Activity of Factor XI.

Blood

Katelyn M Dow, Sarah M Nordstrom, Brandon C Sos, Richard C Davis, Aldons J Lusis, Ethan J Weiss

Increased Thrombosis in Vivo and Altered Coagulation in Vitro in STAT5AB-Deficient Mice.

Blood

Sarah M Nordstrom, Brandon C Sos, Katelyn M Dow, Tina S Fong, Robert E Levy, Jonathan Dukes, Ethan J Weiss

Sex differences in thrombosis.

Expert review of hematology

Nordstrom SM, Weiss EJ

Sex differences in thrombosis in mice are mediated by sex-specific growth hormone secretion patterns.

The Journal of clinical investigation

Wong JH, Dukes J, Levy RE, Sos B, Mason SE, Fong TS, Weiss EJ

Role of thrombin signalling in platelets in haemostasis and thrombosis.

Nature

Sambrano GR, Weiss EJ, Zheng YW, Huang W, Coughlin SR

Protease-activated receptors 1 and 4 are shut off with distinct kinetics after activation by thrombin.

The Journal of biological chemistry

Shapiro MJ, Weiss EJ, Faruqi TR, Coughlin SR

PAR3 is a cofactor for PAR4 activation by thrombin.

Nature

Nakanishi-Matsui M, Zheng YW, Sulciner DJ, Weiss EJ, Ludeman MJ, Coughlin SR

Higher prevalence of GPIIIa PlA2 polymorphism in siblings of patients with premature coronary heart disease.

Archives of pathology & laboratory medicine

Goldschmidt-Clermont PJ, Coleman LD, Pham YM, Cooke GE, Shear WS, Weiss EJ, Kral BG, Moy TF, Yook RM, Blumenthal RS, Becker DM, Becker LC, Bray PF

PlA1/A2 polymorphism of platelet glycoprotein IIIa and risk of cardiovascular disease.

Lancet (London, England)

Bray PF, Weiss EJ, Tayback M, Goldschmidt-Clermont PJ

Self-expanding metal stent for obstructing adenocarcinoma of the sigmoid.

Gastrointestinal endoscopy

Vandervoort J, Weiss EJ, Somnay K, Tham TC, Wong RC, Carr-Locke DL

A polymorphism of a platelet glycoprotein receptor as an inherited risk factor for coronary thrombosis.

The New England journal of medicine

Weiss EJ, Bray PF, Tayback M, Schulman SP, Kickler TS, Becker LC, Weiss JL, Gerstenblith G, Goldschmidt-Clermont PJ

A monoclonal antibody (SZ21) specific for platelet GPIIIa distinguishes P1A1 from P1A2.

Tissue antigens

Weiss EJ, Goldschmidt-Clermont PJ, Grigoryev D, Jin Y, Kickler TS, Bray PF