Ethan Weiss, MD | Center for Prevention of Heart and Vascular Disease

Assoc Prof In Res

M_MED-CORE-CARD

CLINICAL INTERESTS: Dr. Ethan Weiss is a cardiologist specializing in general cardiology. His special interests include preventive cardiology, genetics of coronary disease, risk assessment, and heart disease in the young.

RESEARCH INTERESTS: In his research, Dr. Weiss uses genetic models to better understand the mechanism of metabolic disorders such as obesity, fatty liver disease, and diabetes. He also studies the blood clotting system and has interest in identifying novel ways to safely block clots associated with diseases such as heart attack and stroke without causing an increase in bleeding.

Publications

Safety and efficacy of a novel ANGPTL4 inhibitory antibody for lipid lowering: results from phase 1 and phase 1b/2a clinical studies.

Lancet (London, England)

Cummings BB, Joing MP, Bouchard PR, Milton MN, Moesta PF, Ramanan V, Lane A, Hirman J, Trauger JW, Maratos-Flier E, Voznesensky A, Splawski I, Nimonkar AV, Flaherty MM, Yi BA, Meyers D, Huet F, Sahambi SK, Yates DP, Hom D, Hinder M, Basson CT, O'Donnell C, Siegelman ES, Garrett CE, Lehrer-Graiwer J, Juliano RA, Weiss EJ

An ANGPTL4 inhibitory antibody safely improves lipid profiles in non-human primates.

EBioMedicine

Cummings BB, Bouchard PR, Milton MN, Moesta PF, Ramanan V, Trauger JW, Maratos-Flier E, Voznesensky A, Splawski I, Nimonkar AV, DiPetrillo K, LaSala D, Pan M, Flaherty MM, Huet F, Sahambi SK, Dong J, Knee D, Cebe R, Huber T, Lehrer-Graiwer J, Juliano RA, Weiss EJ

Relationship of Fat Mass Ratio, a Biomarker for Lipodystrophy, With Cardiometabolic Traits.

Diabetes

Agrawal S, Luan J, Cummings BB, Weiss EJ, Wareham NJ, Khera AV

An evolutionary trade-off between host immunity and metabolism drives fatty liver in male mice.

Science (New York, N.Y.)

Nikkanen J, Leong YA, Krause WC, Dermadi D, Maschek JA, Van Ry T, Cox JE, Weiss EJ, Gokcumen O, Chawla A, Ingraham HA

Three-dimensional optical body shape and features improve prediction of metabolic disease risk in a diverse sample of adults.

Obesity (Silver Spring, Md.)

Bennett JP, Liu YE, Quon BK, Kelly NN, Leong LT, Wong MC, Kennedy SF, Chow DC, Garber AK, Weiss EJ, Heymsfield SB, Shepherd JA

Use of an mHealth Ketogenic Diet App Intervention and User Behaviors Associated With Weight Loss in Adults With Overweight or Obesity: Secondary Analysis of a Randomized Clinical Trial.

JMIR mHealth and uHealth

Falkenhain K, Locke SR, Lowe DA, Lee T, Singer J, Weiss EJ, Little JP

Assessment of clinical measures of total and regional body composition from a commercial 3-dimensional optical body scanner.

Clinical nutrition (Edinburgh, Scotland)

Bennett JP, Liu YE, Quon BK, Kelly NN, Wong MC, Kennedy SF, Chow DC, Garber AK, Weiss EJ, Heymsfield SB, Shepherd JA

Effect of carbohydrate-restricted dietary interventions on LDL particle size and number in adults in the context of weight loss or weight maintenance: a systematic review and meta-analysis.

The American journal of clinical nutrition

Falkenhain K, Roach LA, McCreary S, McArthur E, Weiss EJ, Francois ME, Little JP

Keyto App and Device versus WW App on Weight Loss and Metabolic Risk in Adults with Overweight or Obesity: A Randomized Trial.

Obesity (Silver Spring, Md.)

Falkenhain K, Locke SR, Lowe DA, Reitsma NJ, Lee T, Singer J, Weiss EJ, Little JP

The Impact of Carbohydrate Restriction and Nutritional Ketosis on Cardiovascular Health.

Dylan Lowe, Kevin C. Corbit, Ethan J. Weiss

A Mediterranean-Based Ketogenic Diet Application Compared to a Calorie-Restricted Low-Fat Diet Application on Cardiometabolic Risk in Adults With Overweight or Obesity.

Current Developments in Nutrition

Kaja Falkenhain, Sean Locke, Dylan Lowe, Nicholas Reitsma, Ethan Weiss, Jonathan Little

Caution Against Overinterpreting Time-Restricted Eating Results-Reply.

JAMA internal medicine

Weiss EJ, Lowe DA, Vittinghoff E

4ß-hydroxycholesterol is a pro-lipogenic factor that promotes SREBP1c expression and activity through Liver X-receptor.

Journal of lipid research

Moldavski O, Zushin PH, Berdan CA, Van Eijkeren RJ, Jiang X, Qian M, Ory DS, Covey DF, Nomura DK, Stahl A, Weiss EJ, Zoncu R

Effects of Time-Restricted Eating on Weight Loss and Other Metabolic Parameters in Women and Men With Overweight and Obesity: The TREAT Randomized Clinical Trial.

JAMA internal medicine

Lowe DA, Wu N, Rohdin-Bibby L, Moore AH, Kelly N, Liu YE, Philip E, Vittinghoff E, Heymsfield SB, Olgin JE, Shepherd JA, Weiss EJ

Comparing the Keyto App and Device with Weight Watchers' WW App for Weight Loss: Protocol for a Randomized Trial.

JMIR research protocols

Locke SR, Falkenhain K, Lowe DA, Lee T, Singer J, Weiss EJ, Little JP

Diet Quality and Visceral Adiposity among a Multiethnic Population of Young, Middle, and Older Aged Adults.

Current Developments in Nutrition

Panizza CE, Wong MC, Kelly N, Liu YE, Shvetsov YB, Lowe DA, Weiss EJ, Heymsfield SB, Kennedy S, Boushey CJ, Maskarinec G, Shepherd JA

MON-LB107 Treat: A Randomized Controlled Trial Examining the Effects of Time Restricted Eating on Weight Loss and Metabolic Markers.

Journal of the Endocrine Society

Dylan A Lowe, Ethan James Weiss, Jeffrey E Olgin, Eric Vittinghoff, John A Shepherd, Steven B Heymsfield, Linnea Rohdin-Bibby, Nisa Kelly, Nancy Wu

Billy Idol.

Perspectives in biology and medicine

Weiss EJ

Adipocyte JAK2 mediates spontaneous metabolic liver disease and hepatocellular carcinoma.

JCI insight

Corbit KC, Wilson CG, Lowe D, Tran JL, Vera NB, Clasquin M, Mattis AN, Weiss EJ

Adipocyte JAK2 Regulates Hepatic Insulin Sensitivity Independently of Body Composition, Liver Lipid Content, and Hepatic Insulin Signaling.

Diabetes

Corbit KC, Camporez JPG, Edmunds LR, Tran JL, Vera NB, Erion DM, Deo RC, Perry RJ, Shulman GI, Jurczak MJ, Weiss EJ

Growth hormone receptor antagonism with pegvisomant in insulin resistant non-diabetic men: A phase II pilot study.

F1000Research

Lee AP, Mulligan K, Schambelan M, Murphy EJ, Weiss EJ

Adipocyte JAK2 mediates growth hormone-induced hepatic insulin resistance.

JCI insight

Corbit KC, Camporez JPG, Tran JL, Wilson CG, Lowe DA, Nordstrom SM, Ganeshan K, Perry RJ, Shulman GI, Jurczak MJ, Weiss EJ

Hepatocyte-Specific Disruption of CD36 Attenuates Fatty Liver and Improves Insulin Sensitivity in HFD-Fed Mice.

Endocrinology

Wilson CG, Tran JL, Erion DM, Vera NB, Febbraio M, Weiss EJ

Disruption of JAK2 in adipocytes impairs lipolysis and improves fatty liver in mice with elevated GH.

Molecular endocrinology (Baltimore, Md.)

Nordstrom SM, Tran JL, Sos BC, Wagner KU, Weiss EJ

HIV infection is associated with decreased thrombin generation.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

Hsue PY, Scherzer R, Grunfeld C, Nordstrom SM, Schnell A, Kohl LP, Nitta E, Martin JN, Deeks SG, Weiss EJ

Liver-derived IGF-I contributes to GH-dependent increases in lean mass and bone mineral density in mice with comparable levels of circulating GH.

Molecular endocrinology (Baltimore, Md.)

Nordstrom SM, Tran JL, Sos BC, Wagner KU, Weiss EJ

Abrogation of growth hormone secretion rescues fatty liver in mice with hepatocyte-specific deletion of JAK2.

The Journal of clinical investigation

Sos BC, Harris C, Nordstrom SM, Tran JL, Balázs M, Caplazi P, Febbraio M, Applegate MA, Wagner KU, Weiss EJ

Genetic regulation of platelet receptor expression and function: application in clinical practice and drug development.

Arteriosclerosis, thrombosis, and vascular biology

Williams MS, Weiss EJ, Sabatine MS, Simon DI, Bahou WF, Becker LC, Parise LV, Dauerman HL, French PA, Smyth SS, Becker RC

Increased thrombosis susceptibility and altered fibrin formation in STAT5-deficient mice.

Blood

Nordstrom SM, Holliday BA, Sos BC, Smyth JW, Levy RE, Dukes JW, Lord ST, Weiss EJ

A Novel Tissue Factor Resistance Locus on Mouse Chromosome 11 Confers Protection from Thrombosis through Reduced Activity of Factor XI.

Blood

Katelyn M Dow, Sarah M Nordstrom, Brandon C Sos, Richard C Davis, Aldons J Lusis, Ethan J Weiss

Increased Thrombosis in Vivo and Altered Coagulation in Vitro in STAT5AB-Deficient Mice.

Blood

Sarah M Nordstrom, Brandon C Sos, Katelyn M Dow, Tina S Fong, Robert E Levy, Jonathan Dukes, Ethan J Weiss

Sex differences in thrombosis.

Expert review of hematology

Nordstrom SM, Weiss EJ

Sex differences in thrombosis in mice are mediated by sex-specific growth hormone secretion patterns.

The Journal of clinical investigation

Wong JH, Dukes J, Levy RE, Sos B, Mason SE, Fong TS, Weiss EJ

Increased Thrombosis in Male Versus Female Mice Is Mediated by Pulsatile Growth Hormone Secretion Possibly through Inhibition of TFPI Expression in the Vasculature.

Blood

Joshua H. Wong, Robert E. Levy, Jonathan Dukes, Sara A. Mason, Brandon Sos, Ethan J. Weiss

Protection against thrombosis in mice lacking PAR3.

Blood

Weiss EJ, Hamilton JR, Lease KE, Coughlin SR

Role of thrombin signalling in platelets in haemostasis and thrombosis.

Nature

Sambrano GR, Weiss EJ, Zheng YW, Huang W, Coughlin SR

Protease-activated receptors 1 and 4 are shut off with distinct kinetics after activation by thrombin.

The Journal of biological chemistry

Shapiro MJ, Weiss EJ, Faruqi TR, Coughlin SR

Structure-function analysis of protease-activated receptor 4 tethered ligand peptides. Determinants of specificity and utility in assays of receptor function.

The Journal of biological chemistry

Faruqi TR, Weiss EJ, Shapiro MJ, Huang W, Coughlin SR